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Equity Components [Axis] Fixed and intangible assets Deferred Tax Assets Property Plant And Equipment And Intangible Assets Deferred tax assets fixed and intangible assets. Recognized Revenue Associated With The Following License Agreements Table Recognized Revenue Associated with The Following License Agreements [Table] Local Phone Number Property, Plant and Equipment [Line Items] Sale of Stock [Axis] Sale of Stock [Axis] Accrued reimbursement to KKC Accrued Reimbursement to Related Party Accrued reimbursement to related party. Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Transfers, Net, Total Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Transfers, Net Fair value, measurement with unobservable inputs reconciliation, recurring basis, liability, transfers Statement of Cash Flows [Abstract] Directors Director [Member] Income Tax Authority [Domain] Number of square feet under lease Number of Square Feet Under Lease Number of square feet under lease. Organization, Consolidation and Presentation of Financial Statements [Abstract] Property and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Concentration Risk Benchmark [Axis] Document Annual Report Restructuring Reserve [Abstract] Common stock, par value Common Stock, Par or Stated Value Per Share Deferred revenue, long-term Deferred Revenue, Noncurrent Deferred Revenue, Noncurrent, Total Expected weighted average period for recognition of compensation expense Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Long-Lived Tangible Asset [Axis] Vested and expected to vest at end of period Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Common stock authorized Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Maximum Maximum [Member] Kyowa Kirin Co Kyowa Kirin Co [Member] Related Party Transaction [Axis] Related Party Transactions Dividend paid Payment of cash dividend Payments of Dividends Payments of Dividends, Total Level 3 Fair Value, Inputs, Level 3 [Member] Share-based compensation expense APIC, Share-Based Payment Arrangement, Increase for Cost Recognition APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total General and administrative General and Administrative Expense [Member] General and Administrative Expense Member Forfeited Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period Issuance of common stock to purchase asset, shares | shares Stock Issued During Period, Shares, Purchase of Assets Document Financial Statement Error Correction [Flag] Antidilutive Securities Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] City Area Code Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Document Information [Line Items] Schedule of Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Table] Unsold Securities Shares and Warrants Under Agreement Unsold Securities Shares and Warrants Under Agreement Unsold securities shares and warrants under agreement. Common stock voting rights Common Stock, Voting Rights Less: accumulated depreciation Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance General and administrative General and Administrative Expense General and Administrative Expense, Total Description of Business Business Description and Accounting Policies [Text Block] Basic Weighted Average Number of Shares Outstanding, Basic Weighted Average Number of Shares Outstanding, Basic, Total Shares used in calculating basic net loss per share Summary of Activity Related to One-Time Employee Termination Benefits Included in Accrued Liabilities Restructuring and Related Costs [Table Text Block] San Diego California [Member] San Diego California [Member] Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Research and Development Expense, Policy [Policy Text Block] Research and Development Number of warrants exercised Number Of Warrants Exercised Number Of Warrants Exercised Statement [Table] Statement [Table] Schedule of Related Party Transactions, by Related Party [Table] Schedule of Related Party Transactions, by Related Party [Table] Fair Value of Stock Options Weighted-Average Assumptions Used Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Net change Deferred revenue Increase (Decrease) in Contract with Customer, Liability KKC Agreements [Member] Kkc Agreements [Member] Kkc Agreements [Member]. Kkc Agreements [Member] Document Fiscal Period Focus Document Fiscal Period Focus Short-term Investments Short-Term Investments Investment, Policy [Policy Text Block] Revenue from customers Revenue from Contract with Customer Benchmark [Member] Accrued legal and professional services expenses Accrued Professional Fees, Current Statement [Line Items] Statement [Line Items] Payment of financing costs Payments of Financing Costs Payments of Financing Costs, Total Total anti-dilutive shares Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Other Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount Lease, Cost Total lease costs included in general and administrative expenses Warrants Warrant [Member] Deferred Tax Liabilities and Assets Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Accounts receivable Accounts Receivable, after Allowance for Credit Loss, Current Accounts Receivable, after Allowance for Credit Loss, Current, Total Common Shares Common Stock [Member] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Cash and Cash Equivalents, at Carrying Value, Total Cash and cash equivalents at beginning of the year Cash and cash equivalents at end of the year Share-Based Compensation Expense for Stock Awards Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Total upfront payment receivable for grant of rights Total Upfront Payment Receivable For Grant Of Rights Total upfront payment receivable for grant of rights. Rule 10b51 Arr Modified Rule 10b51 Arr Modified [Flag] Rule 10b51 Arr Modified [Flag] Risk Free Interest Rate Measurement Input, Risk Free Interest Rate [Member] Summary of Stock Option Activity and Related Data Disclosure of Share-Based Compensation Arrangements by Share-Based Payment Award [Table Text Block] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Contract with customer liability revenue recognized performance obligations no longer commence. Contract With Customer Liability Revenue Recognized Performance Obligations No Longer Commence Revenue recognized for performance obligations that will no longer commence Fair Value Measurements Fair Value of Financial Instruments, Policy [Policy Text Block] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Pass Through Services [Member] Pass through services member. Interest and Dividend Income Interest Income [Policy Text Block] Disclosure of accounting policy for interest income. Domestic Income (Loss) from Continuing Operations before Income Taxes, Domestic 2008 Omnibus Plan Two Thousand And Eight Omnibus Plan [Member] Two thousand and eight omnibus plan. Measurement input weighted-average grant date fair value. Measurement Input Weighted-Average Grant Date Fair Value [Member] Weighted-average grant date fair value Cover [Abstract] Cover [Abstract] CARES Act [Member] CARES Act [Member] CARES Act [Member] Dividends [Domain] Document Fiscal Year Focus Document Fiscal Year Focus Presage License Agreement Presage License Agreement [Member] Presage License Agreement. Sale of Stock [Domain] Re-measurement of right-of-use asset for direct costs associated with lease modification Remeasurement of Right of Use Asset for Direct Costs Associated with Lease Modification Remeasurement of right of use asset for direct costs associated with lease modification. First milestone payment Upfront And Milestone Payments Upfront and milestone payments. Before tax reform member. Before Tax Reform [Member] Before Tax Reform [Member] Security Exchange Name Security Exchange Name Share-based compensation arrangement by share-based payment award, expiration period Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period Common stock subject to repurchase or forfeiture Weighted Average Number of Shares, Common Stock Subject to Repurchase or Cancellation Sale of shares and warrants under agreement Sale Of Shares And Warrants Under Agreement Sale of shares and warrants under agreement. Accounting Standards Update and Change in Accounting Principle [Table] Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Preferred Stock, Shares Issued Preferred Stock, Shares Issued, Total Preferred stock, shares issued Preferred stock, shares authorized Preferred Stock, Shares Authorized Property, Plant and Equipment, Gross Property, Plant and Equipment, Gross, Total Property, Plant and Equipment, Gross, Beginning Balance Property, Plant and Equipment, Gross, Ending Balance Contract with customer asset and liability. Contract with Customer Asset and Liability [Table] Contract with Customer Asset and Liability [Table] Timing of Transfer of Good or Service [Axis] Operating Lease right-of-use assets obtained in exchange for operating lease liabilities Right-of-use assets obtained in exchange for operating lease obligations: Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Forfeited Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Remaining future minimum rental payments Operating Leases Future Minimum Rental Payments Operating leases future minimum rental payments. Business Acquisition, Acquiree [Domain] Legal Entity [Axis] Legal Entity [Axis] Weighted-average shares used in computing net income (loss) per share - basic and diluted Weighted Average Number of Shares Outstanding, Diluted [Abstract] Aggregate Intrinsic Value Share-Based Compensation Arrangement by Share-Based Payment Award, Additional General Disclosures [Abstract] Licensing Arrangements [Abstract] Licensing arrangements [Abstract]. Entity Emerging Growth Company Entity Emerging Growth Company Unbilled Receivables Increase Decrease In Unbilled Receivable Increase Decrease In Unbilled Receivable Amendment Flag Amendment Flag Accrued Liabilities Schedule of Accrued Liabilities [Table Text Block] Type of Adoption [Domain] Accounting Standards Update [Domain] Basis of Accounting, Policy [Policy Text Block] Basis of Presentation and Consolidation Warrant liability costs Income Tax Rate Reconciliation Tax Expense Benefit Warrant Liability Amount Amount of difference between Expected Income Tax Benefit(Expense),Reported Income Tax Benefit (Expense) computed by Applying Domestic Statutory rate to pre tax Income(Loss) from operation in respect of Expenses Attributable to warrants. One-time Employee Termination Benefits Restructuring and Related Activities Disclosure [Text Block] Transaction price relating to the performance obligation Total Transaction Price In Respect Of Colloboration Revenue Total transaction price in respect of colloboration revenue. Leases [Abstract] Warrants outstanding Class of Warrant or Right, Number of Securities Called by Each Warrant or Right Securities Act File Number Adopted agreement date Adopted Agreement Adopted agreement Percentage of reimbursement of pass through costs as revenue Percentage Of Reimbursement Of Pass Through Costs As Revenue Percentage Of Reimbursement Of Pass Through Costs As Revenue Deferred Tax Assets, Gross Total deferred tax assets Purchase Commitment, Excluding Long-term Commitment [Line Items] Purchase Commitment, Excluding Long-Term Commitment [Line Items] Other Liabilities, Total Other Liabilities Other liabilities Balance Sheet Related Disclosures [Abstract] Share-Based Payment Arrangement [Abstract] Warrants and Rights Outstanding, Measurement Input Accounts payable Accounts Payable, Current Accounts Payable, Current, Total Valuation allowance for deferred tax assets Deferred Tax Assets, Valuation Allowance Deferred Tax Assets, Valuation Allowance, Total Costs and Expenses Total operating expenses Auditor Location Auditor Location Expected life (years) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Entity Address, Address Line Two Amendment Description Preferred stock, $0.01 par value; 100 shares authorized; none outstanding Preferred Stock, Value, Issued Preferred Stock, Value, Issued, Total Preferred Stock, Value, Issued, Beginning Balance Preferred Stock, Value, Issued, Ending Balance Entity Small Business Entity Small Business Pre tax Income Loss [Line Items] Entity Shell Company Entity Shell Company Number of operating segments Number of Operating Segments Title of Individual [Axis] Title of Individual [Axis] Number of shares issued and sold Sale of Stock, Number of Shares Issued in Transaction Exercise price Class of Warrant or Right, Exercise Price of Warrants or Rights Financing costs included in accounts payable Financing Costs Included in Accounts Payable Financing costs included in accounts payable. Direct costs Direct Costs Direct costs. Proceeds from the sale of property and equipment Proceeds from the Sale of Property and Equipment Proceeds from the sale of property and equipment. Entity Address, Address Line One Increase in right of use asset balance Increase in Right of Use Asset Balance Increase in right of use asset balance. Inducement Plan [Member] Inducement Plan [Member] Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] BeiGene, Ltd BeiGene, Ltd [Member] BeiGene, Ltd Antidilutive Securities [Axis] Antidilutive Securities [Axis] Expected volatility Measurement Input, Price Volatility [Member] Supplemental Balance Sheet Disclosures [Text Block] Balance Sheet Details Proceeds from maturity of short-term investments Proceeds from Maturities, Prepayments and Calls of Short-Term Investments Torreya Partners LLC Torreya Partners LLC [Member] Torreya partners llc member Income Statement Location [Axis] Income Statement Location [Axis] Variable Lease, Cost Variable lease costs Weighted Average Remaining Contractual Term (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Weighted Average Remaining Contractual Term [Abstract] Share-based compensation arrangement by share-based payment award, options, weighted average remaining contractual term. Presage Biosciences, Inc. Presage Biosciences Inc [Member] Presage Biosciences Inc. Dividend yield Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate Net income (loss) Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total Net loss Deferred revenue Deferred Tax Assets, Deferred Income Prepayment of remaining rent Prepayment of Remaining Rent Prepayment of remaining rent. Purchase Commitment, Excluding Long-term Commitment [Table] Purchase Commitment, Excluding Long-Term Commitment [Table] Amount on reduction in remaining right of use asset and lease liability Amount on Reduction in Remaining Right of Use Asset and Lease Liability Amount on reduction in remaining right of use asset and lease liability. Accrued pre-clinical and clinical trial expenses Accrued Preclinical And Clinical Costs Accrued pre-clinical and clinical trial expenses. Depreciation expense Depreciation, Depletion and Amortization Depreciation, Depletion and Amortization, Total Product and Service [Axis] Contract with customer liability non current Contract with Customer, Liability, Noncurrent Title of 12(b) Security Title of 12(b) Security State tax Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount Adjustments for New Accounting Pronouncements [Axis] Accounting Standards Update [Axis] Cash dividends declared Adjustments to Additional Paid in Capital, Dividends in Excess of Retained Earnings Milestone payment receivable amount Potential Milestone Payments Receivable Potential milestone payments receivable. Change in estimated fair value of liability classified warrants Change in fair value of warrant liability Change in fair value of warrant liability Fair Value, Liability, Recurring Basis, Still Held, Unrealized Gain (Loss) Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities [Abstract] State State and Local Jurisdiction [Member] Segment Reporting, Policy [Policy Text Block] Segment Information Long-Lived Tangible Asset [Domain] Unpaid common stock dividend Cash dividends declared, per share Common Stock, Dividends, Per Share, Declared Tax Reform [Axis] Contract liabilities included in deferred revenue and deferred revenue, net of current portion Contract liabilities, beginning of year Contract liabilities, end of year Contract with Customer, Liability Contract with Customer, Liability, Total Expected milestone payment receivable Expected Milestone Payment Receivable Expected milestone payment receivable. Common stock, shares outstanding Common Stock, Shares, Outstanding Common Stock, Shares, Outstanding, Beginning Balance Common Stock, Shares, Outstanding, Ending Balance Risk-free interest rate Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Share-Based Payment Arrangement [Text Block] Share-based Compensation Deferred Revenue [Member] Deferred revenue. Re-measurement of right-of-use asset and related lease liability upon lease modification Remeasurement of Right of Use Asset and Related Lease Liability Upon Lease Modification Remeasurement of right of use asset and related lease liability upon lease modification. Income Statement Location [Domain] Income Statement Location [Domain] Granted Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Document Type Document Type Other Other Prepaid Expense, Current Number Of Shares For Each Unit Of Restricted Stock Number Of Shares For Each Unit Of Restricted Stock Net Cash Provided by (Used in) Investing Activities Net cash provided by investing activities Stock Compensation Plan Share-Based Payment Arrangement [Member] Counterparty Name [Domain] Net loss—basic Basic Net Income (Loss) Available to Common Stockholders, Basic Net Income (Loss) Available to Common Stockholders, Basic, Total Net cash used in financing activities Net Cash Provided by (Used in) Financing Activities Taxable income percentage. Taxable Income Percentage Taxable income percentage Entity Filer Category Entity Filer Category Expired Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price Balance Sheet Location [Domain] Accrued liabilities Increase (Decrease) in Accrued Liabilities Increase (Decrease) in Accrued Liabilities, Total Pre-Tax loss Information Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] Disclosure of supplemental cash flow information related to operating leases. Disclosure Of Supplemental Cash Flow Information Related To Operating Leases [Table Text Block] Schedule of Supplemental Cash Flow Information Related to Operating Leases Short-term investments Short-term investments Short-Term Investments Short-term Investments, Total Recognized Revenue Associated With The Following License Agreements Line Items Recognized Revenue Associated with The Following License Agreements [Line Items] Nonoperating Income (Expense) Total other income, net Total liabilities Liabilities Total liabilities CyDex License Agreement CyDex License Agreement [Member] CyDex License Agreement. Noncash lease expense Non cash lease expense. Non Cash Lease Expense Purchases of short-term investments Payments to Acquire Short-Term Investments Purchases of short-term investments Interest and dividend income Investment Income, Interest and Dividend Investment Income, Interest and Dividend, Total Impairment charges Asset Impairment Charges Asset Impairment Charges, Total Total stockholders' equity Beginning Balance Ending Balance Equity, Attributable to Parent Total stockholders' equity Employees Employees [Member] Employees. Documents Incorporated by Reference [Text Block] Documents Incorporated by Reference At-the-market offering agreement, description At-the-Market Offering Agreement Description At-the-market offering agreement description. Revenue recognized for performance obligations that will no longer commence Contract with Customer, Liability, Cumulative Catch-up Adjustment to Revenue, Modification of Contract Net income (loss) Net income (loss) Other income (expense): Nonoperating Income (Expense) [Abstract] Upfront payment Up Front Payment Up Front Payment State tax Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent Number of square feet under lease Area of Land Rights and the rights agreement expiration description Rights and the Rights Agreement Expiration Description Rights and the rights agreement expiration description. Statement of Financial Position [Abstract] Weighted average shares used in calculating diluted loss per share Diluted Weighted Average Number of Shares Outstanding, Diluted Shares used in calculating diluted net loss per share Other Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent Reconciliation of Income Taxes Computed at U.S Federal Statutory Tax Rates to Income Tax Expense Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Impairment of long-lived assets Impairment of Long-Lived Assets to be Disposed of Decrease in ROU asset balance Operating Lease, Right-of-Use Asset, Periodic Reduction Effective Income Tax Rate, Continuing Operations, Total Effective Income Tax Rate Reconciliation, Percent Future aggregate milestone payments Milestone Payments, Maximum Amount Milestone payments, maximum amount. Use of Estimates Use of Estimates, Policy [Policy Text Block] Income Taxes Income Tax Disclosure [Text Block] Beginning Balance Ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Leasehold improvements Leasehold Improvements [Member] Income Tax Authority [Axis] Fair Value Disclosures [Abstract] Operating expenses: Costs and Expenses [Abstract] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Fair Value, Measurement Frequency [Domain] Measurement Frequency [Domain] Type of Restructuring [Domain] Other Commitments [Axis] Accrued compensation and benefits Employee-related Liabilities, Current Employee-related Liabilities, Current, Total Business Acquisition [Axis] Cash and cash equivalents at end of the year Cash and cash equivalents at beginning of the year Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total Deferred revenue Deferred Revenue, Current Deferred Revenue, Current, Total Income Tax Disclosure [Abstract] ATM Sales Agreement At The Market Sale Agreement [Member] At-the-market equity offering sales agreement.